Formulation, Evaluation and Optimization of Controlled Release Hydrogel Microspheres for Colon Targeted Drug Delivery
نویسندگان
چکیده
The purpose of this research was to established new polysaccharide for the colon targeted drug delivery system, its formulation and in vitro and in vivo evaluation. Microspheres containing chitosan and bora rice were prepared by simple emulsification phase separation technique using glutaraldehyde as cross linking agent and model drug used was glipizide. Results of trial batches indicated that polymer to drug ratio and stirring speed affects characteristics of microspheres. Microspheres were discrete, spherical and free flowing. Microspheres exhibited small particle size, higher percentage yield and also showed higher percentage of drug entrapment efficiency. A 3 full factorial design was employed to study the effect of independent variables, polymer to drug ratio (A), and stirring speed (B) on dependent variables, particle size, swelling index, drug entrapment efficiency and percentage drug release. The optimized batch C2 exhibited satisfactory drug entrapment efficiency 63% and drug release was also controlled for more than 24 hours. The polymer to drug ratio had a more significant effect on the dependent variables. In vivo gamma scintigraphy study of optimized chitosan-bora rice microsphere demonstrated degradation of microspheres whenever they reached to the colon. Hence bora rice is potential polysaccharide for colon targeted drug delivery system.
منابع مشابه
Gelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation
A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...
متن کاملGelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation
A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...
متن کاملβ- Galactosidase mediated release characteristics of lornoxicam loaded guar gum microspheres: evaluation and product development
The present investigation was aimed at developing a novel colon targeted system of lornoxicam based on the use of a combination of pH dependent system (to prevent the premature release of drug in the upper GIT) and enzymatically degradation system (to ensure the specificity of drug release in the colon). The drug loaded guar gum microspheres prepared by emulsification cross-linking method were ...
متن کاملDe-Esterified Tragacanth Microspheres Loaded into Eudragit S-100 Coated Capsules for Colon-Targeted Delivery
The objective of this study was to develop a novel bacterially-triggered micro-particular system of de-esterified tragacanth (DET) in combination with Eudragit S-100 coated capsules for colon drug delivery of 5-fluorouracil (5-FU) using microemulsion method. The loading study was conducted at different drug-to-polymer ratios and cross-linker concentrations. The maximum loading efficiency was ac...
متن کاملDe-Esterified Tragacanth Microspheres Loaded into Eudragit S-100 Coated Capsules for Colon-Targeted Delivery
The objective of this study was to develop a novel bacterially-triggered micro-particular system of de-esterified tragacanth (DET) in combination with Eudragit S-100 coated capsules for colon drug delivery of 5-fluorouracil (5-FU) using microemulsion method. The loading study was conducted at different drug-to-polymer ratios and cross-linker concentrations. The maximum loading efficiency was ac...
متن کامل